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- Morten Grötli
Morten Grötli
Professor
Institutionen för kemi och molekylärbiologiOm Morten Grötli
The focus of the Grøtli Lab is the use of synthetic organic chemistry to produce novel compounds for the study of problems important in cell biology and medicine. Such compounds are interesting both as potential therapeutics and as experimental tools for understanding the physiological roles of the target proteins. Two types of compounds are of special interest: probes for visualization (e.g. fluorescence-based sensors for detection of enzymatic activity in vivo and in vitro; fluorescent-nucleic acid base analogues), and probes for selective perturbation of biological processes (e.g. kinase inhibitors). For more information see Grøtli Lab website.
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Design and application of a fluorescent probe for imaging of endogenous Bruton's tyrosine kinase with preserved enzymatic
activity
Anna Paraskevi Valaka, Hampus Nyström, Liliana Håversen, Carlos Benitez-Martin, Clara Schäfer, Woo Suk Jang, Alessandro Camponeschi, Joakim Andreasson, Jan Borén, Morten Grötli
RSC CHEMICAL BIOLOGY - 2025 -
Click and shift: the effect of triazole on solvatochromic
dyes
Jean Rouillon, Carlos Benitez-Martin, Morten Grötli, Joakim Andreasson
PHYSICAL CHEMISTRY CHEMICAL PHYSICS - 2025 -
An automated positive selection screen in yeast provides support for boron-containing compounds as inhibitors of SARS-CoV-2 main
protease
Sunniva Sigurdardóttir, Suélen Fernandes Silva, Ievgeniia Tiukova, Hanna Alalam, Ross D. King, Morten Grötli, Leif A Eriksson, Per Sunnerhagen
Microbiology Spectrum - 2024 -
Exploring Subsite Selectivity within Plasmodium vivax N Myristoyltransferase Using Pyrazole-Derived
Inhibitors
Diego Rodríguez-Hernández, Michael K. Fenwick, Rachael Zigweid, Banumathi Sankaran, Peter J. Myler, Per Sunnerhagen, Alexis Kaushansky, Bart L. Staker, Morten Grötli
JOURNAL OF MEDICINAL CHEMISTRY - 2024 -
All-photonic kinase inhibitors: light-controlled release-and-report
inhibition
Cassandra L. Fleming, Carlos Benitez-Martin, Elin Bernson, Yongjin Xu, Linnea Kristenson, Tord Inghardt, Thomas Lundback, Fredrik Thoren, Morten Grötli, Joakim Andreasson
CHEMICAL SCIENCE - 2024 -
Serendipitous Identification of a Covalent Activator of Liver Pyruvate
Kinase
Umberto Battisti, Chunxia Gao, Oscar Nilsson, Fady Akladios, A. Lulla, A. Bogucka, Amalyn Nain-Perez, Liliana Håversen, W. Kim, Jan Borén, M. Hyvonen, M. Uhlen, A. Mardinoglu, Morten Grötli
Chembiochem - 2023 -
Fluorescent Molecular Photoswitches for the Generation of All-Optical Encryption
Keys
C. Benitez-Martin, J. Rouillon, Morten Grötli, J. Andréasson
Chemphotochem - 2023 -
Exploration of Novel Urolithin C Derivatives as Non-Competitive Inhibitors of Liver Pyruvate
Kinase
Umberto Battisti, Leticia Monjas, Fady Akladios, Josipa Matic, Eric Andresen, Carolin H. Nagel, Malin Hagkvist, Liliana Håversen, W. Kim, M. Uhlen, Jan Borén, A. Mardinoglu, Morten Grötli
Pharmaceuticals - 2023 -
Tuning liver pyruvate kinase activity up or down with a new class of allosteric
modulators
Amalyn Nain-Perez, Oscar Nilsson, A. Lulla, Liliana Håversen, P. Brear, Sara Liljenberg, M. Hyvonen, Jan Borén, Morten Grötli
European Journal of Medicinal Chemistry - 2023 -
Ellagic Acid and Its Metabolites as Potent and Selective Allosteric Inhibitors of Liver Pyruvate
Kinase
Umberto Battisti, Chunxia Gao, Fady Akladios, W. Kim, H. Yang, C. Bayram, I. Bolat, M. Kiliclioglu, N. Yuksel, O. O. Tozlu, C. Zhang, J. Sebhaoui, S. Iqbal, S. Shoaie, A. Hacimuftuoglu, S. Yildirim, H. Turkez, M. Uhlen, Jan Borén, A. Mardinoglu, Morten Grötli
Nutrients - 2023 -
Development of Dicationic Bisguanidine-Arylfuran Derivatives as Potent Agents against Gram-Negative
Bacteria.
Catarina Bourgard, Diego Rodríguez-Hernández, Anastasia Rudenko, Carolin Rutgersson, Martin Palm, D. G. Joakim Larsson, Anne Farewell, Morten Grøtli, Per Sunnerhagen
Antibiotics - 2022 -
Anthraquinone derivatives as ADP-competitive inhibitors of liver pyruvate
kinase
Amalyn Nain-Perez, Anders Füchtbauer, Liliana Håversen, A. Lulla, Chunxia Gao, Josipa Matic, Letitia Monjas, Alexandra Rodriguez, P. Brear, W. Kim, M. Hyvonen, Jan Borén, A. Mardinoglu, M. Uhlen, Morten Grötli
European Journal of Medicinal Chemistry - 2022 -
Design and development of photoswitchable DFG-Out RET kinase
inhibitors
Yongjin Xu, Chunxia Gao, Måns Andreasson, Liliana Håversen, Marta Carrasco, Cassandra L. Fleming, T. Lundback, J. Andreasson, Morten Grötli
European Journal of Medicinal Chemistry - 2022 -
Environmentally friendly catechol-based synthesis of
dibenzosultams
Sara Liljenberg, Amalyn Nain-Perez, Oscar Nilsson, Josipa Matic, Morten Grötli
New Journal of Chemistry - 2022 -
Design and development of a photoswitchable DFG-out kinase
inhibitor
Yongjin Xu, Chunxia Gao, Liliana Håversen, T. Lundback, J. Andreasson, Morten Grötli
Chemical Communications - 2021 -
A genetic trap in yeast for inhibitors of SARS-CoV-2 Main
Protease.
Hanna Alalam, Sunniva Sigurdardóttir, Catarina Bourgard, Ievgeniia Tiukova, Ross D King, Morten Grøtli, Per Sunnerhagen
mSystems - 2021 -
A small molecule targeting human MEK1/2 enhances ERK and p38 phosphorylation under oxidative stress or with
phenothiazines.
Michal Otreba, Johanna Johansson Sjölander, Morten Grøtli, Per Sunnerhagen
Life (Basel) - 2021 -
Discovery of Functional Alternatively Spliced PKM Transcripts in Human
Cancers
X. Y. Li, W. Kim, M. Arif, Chunxia Gao, A. Hober, D. Kotol, L. Strandberg, B. Forsstrom, A. Sivertsson, P. Oksvold, H. Turkez, Morten Grötli, Y. Sato, H. Kume, S. Ogawa, Jan Borén, J. Nielsen, M. Uhlen, C. Zhang, A. Mardinoglu
Cancers - 2021 -
Interbase-FRET binding assay for
pre-microRNAs
Mattias Bood, A. W. del Nogal, J. R. Nilsson, F. Edfeldt, A. Dahlen, M. Lemurell, L. M. Wilhelmsson, Morten Grötli
Scientific Reports - 2021 -
Getting DNA and RNA out of the dark with 2CNqA: a bright adenine analogue and interbase FRET
donor
A. W. del Nogal, Anders Füchtbauer, Mattias Bood, J. R. Nilsson, M. S. Wranne, S. Sarangamath, P. Pfeiffer, V. S. Rajan, A. H. El-Sagheer, A. Dahlen, T. Brown, Morten Grötli, L. M. Wilhelmsson
Nucleic Acids Research - 2020 -
Peroxiredoxin promotes longevity and H2O2-resistance in yeast through redox-modulation of protein kinase
A
Friederike Roger, C. Picazo, W. Reiter, M. Libiad, Chikako Asami, Sarah Hanzén, Chunxia Gao, G. Lagniel, Niek Welkenhuysen, J. Labarre, Thomas Nyström, Morten Grötli, M. Hartl, M. B. Toledano, Mikael Molin
eLife - 2020 -
A redox-sensitive thiol in Wis1 modulates the fission yeast MAPK response to H2O2 and is the target of a small
molecule.
Johanna J Sjölander, Agata Tarczykowska, Cecilia Picazo, Itziar Cossio, Itedale Namro Redwan, Chunxia Gao, Carlos Solano, Michel B Toledano, Morten Grøtli, Mikael Molin, Per Sunnerhagen
Molecular and Cellular Biology - 2020 -
Lighting Up DNA with the Environment-Sensitive Bright Adenine Analogue
qAN4
A. F. F?chtbauer, M. S. Wranne, S. Sarangamath, Mattias Bood, A. H. El-Sagheer, T. Brown, H. Grad?n, Morten Grötli, L. M. Wilhelmsson
Chempluschem - 2020 -
On-Command Regulation of Kinase Activity using Photonic
Stimuli
Cassandra L. Fleming, Morten Grötli, J. Andreasson
ChemPhotoChem - 2019 -
A Fluorescent Kinase Inhibitor that Exhibits Diagnostic Changes in Emission upon
Binding
Cassandra L. Fleming, Patrick A Sandoz, Tord Inghardt, Björn Önfelt, Morten Grøtli, Joakim Andréasson
Angewandte Chemie - International Edition - 2019 -
Shining New Light on the Spiropyran Photoswitch: A Photocage Decides between cis-trans or Spiro-Merocyanine
Isomerization
Cassandra L. Fleming, S. M. Li, Morten Grötli, J. Andreasson
Journal of the American Chemical Society - 2018 -
Synthesis, oligonucleotide incorporation and fluorescence properties in DNA of a bicyclic thymine
analogue
Christopher P. Lawson, A. F. Fuchtbauer, M. S. Wranne, T. Giraud, T. Floyd, B. Dumat, N. K. Andersen, A. H. El-Sagheer, T. Brown, H. Graden, L. M. Wilhelmsson, Morten Grötli
Scientific Reports - 2018 -
Drug Repositioning for Effective Prostate Cancer
Treatment
B. Turanli, Morten Grötli, Jan Borén, J. Nielsen, M. Uhlen, K. Y. Arga, A. Mardinoglu
Frontiers in Physiology - 2018 -
Fluorescent nucleobase analogues for base-base FRET in nucleic acids: Synthesis, photophysics and
applications
Mattias Bood, Sangamesh Sarangamath, Moa S. Wranne, Morten Grøtli, Marcus Wilhelmsson
Beilstein Journal of Organic Chemistry - 2018 -
Pulse-shaped two-photon excitation of a fluorescent base analogue approaches single-molecule
sensitivity
R. S. Fisher, D. Nobis, A. F. Füchtbauer, Mattias Bood, Morten Grøtli, L. M. Wilhelmsson, A. C. Jones, S. W. Magennis
Physical Chemistry Chemical Physics - 2018 -
Pentacyclic adenine: a versatile and exceptionally bright fluorescent DNA base
analogue
Mattias Bood, A. F. Fuchtbauer, M. S. Wranne, J. J. Ro, S. Sarangamath, A. H. El-Sagheer, D. L. M. Rupert, R. S. Fisher, S. W. Magennis, A. C. Jones, F. Hook, T. Brown, B. H. Kim, A. Dahlen, L. M. Wilhelmsson, Morten Grötli
Chemical Science - 2018 -
Plasmodium dihydrofolate reductase is a second enzyme target for the antimalarial action of
triclosan
E. Bilsland, L. van Vliet, K. Williams, J. Feltham, Marta Carrasco, W. L. Fotoran, E. F. G. Cubillos, G. Wunderlich, Morten Grötli, F. Hollfelder, V. Jackson, R. D. King, S. G. Oliver
Scientific Reports - 2018 -
Improving the economics of NASH/NAFLD treatment through the use of systems
biology
J. Bosley, C. Boren, S. Lee, Morten Grötli, J. Nielsen, M. Uhlen, Jan Borén, A. Mardinoglu
Drug Discovery Today - 2017 -
Network analyses identify liver-specific targets for treating liver
diseases.
Sunjae Lee, Cheng Zhang, Zhengtao Liu, Martina Klevstig, Bani Mukhopadhyay, Mattias Bergentall, Resat Cinar, Marcus Ståhlman, Natasha Sikanic, Joshua K Park, Sumit Deshmukh, Azadeh M Harzandi, Tim Kuijpers, Morten Grøtli, Simon J Elsässer, Brian D Piening, Michael Snyder, Ulf Smith, Jens Nielsen, Fredrik Bäckhed, George Kunos, Mathias Uhlen, Jan Borén, Adil Mardinoglu
Molecular systems biology - 2017 -
Toward Complete Sequence Flexibility of Nucleic Acid Base Analogue
FRET
M. S. Wranne, A. F. Fuchtbauer, B. Dumat, Mattias Bood, A. H. El-Sagheer, T. Brown, H. Graden, Morten Grötli, L. M. Wilhelmsson
Journal of the American Chemical Society - 2017 -
On the use of diarylmaleimide derivatives in biological contexts: An investigation of the photochromic properties in aqueous
solution
C. Fleming, P. Remon, S. Li, N. A. Simeth, B. Konig, Morten Grötli, J. Andreasson
Dyes and Pigments - 2017 -
An acido- and photochromic molecular device that mimics triode
action
P. Remón, Shiming Li, Morten Grötli, U. Pischel, Joakim Andréasson
Chemical Communications - 2016 -
Flexibility is important for inhibition of the MDM2/p53 protein-protein interaction by cyclic
β-hairpins
Emma Danelius, Mariell Pettersson, Matilda Bred, Jaeki Min, M. Brett Waddell, R. Kiplin Guy, Morten Grøtli, Mate Erdelyi
Organic and Biomolecular Chemistry - 2016 -
7-(Benzofuran-2-yl)-7-deazadeoxyguanosine as a fluorescence turn-ON probe for single-strand DNA binding
protein
M. Tokugawa, Y. Masaki, J. C. Canggadibrata, K. Kaneko, T. Shiozawa, T. Kanamori, Morten Grøtli, Marcus Wilhelmsson, M. Sekine, K. Seio
Chemical Communications - 2016 -
Defects in the calcium-binding region drastically affect the cadherin-like domains of RET tyrosine
kinase
Chunxia Gao, Morten Grøtli, Leif A Eriksson
Physical Chemistry Chemical Physics - 2016 -
Arsenic Directly Binds to and Activates the Yeast AP-1-Like Transcription Factor
Yap8.
Nallani Vijay Kumar, Jianbo Yang, Jitesh K Pillai, Swati Rawat, Carlos Solano, Abhay Kumar, Morten Grøtli, Timothy L Stemmler, Barry P Rosen, Markus J. Tamás
Molecular and cellular biology - 2016 -
Chroman-4-one and chromone based somatostatin beta-turn
mimetics
Maria Fridén-Saxin, Tina Seifert, Marcus Malo, Krystle da Silva Andersson, Nils Pemberton, Christine Dyrager, Annika Friberg, Kristian Dahlén, Erik A A Wallén, Morten Grøtli, Kristina Luthman
European Journal of Medicinal Chemistry - 2016 -
Structural Insights into the Polyphyletic Origins of Glycyl tRNA
Synthetases
M. I. Valencia-Sanchez, A. Rodriguez-Hernandez, Rubén Ferreira, H. A. Santamaria-Suarez, M. Arciniega, A. C. Dock-Bregeon, D. Moras, B. Beinsteiner, H. Mertens, D. Svergun, L. G. Brieba, Morten Grøtli, A. Torres-Larios
Journal of Biological Chemistry - 2016 -
Second-Generation Fluorescent Quadracyclic Adenine Analogues: Environment-Responsive Probes with Enhanced
Brightness
B. Dumat, Mattias Bood, Moa Sandberg Wranne, Christopher P. Lawson, Anders Foller Larsen, S. Preus, J. Streling, H. Gradén, E. Wellner, Morten Grøtli, Marcus Wilhelmsson
Chemistry - A European Journal - 2015 -
A Caged Ret Kinase Inhibitor and its Effect on Motoneuron Development in Zebrafish
Embryos
David Bliman, Jesper Nilsson, Petronella Kettunen, Joakim Andréasson, Morten Grøtli
Scientific Reports - 2015 -
8-Triazolylpurines: Towards Fluorescent Inhibitors of the MDM2/p53
Interaction
Mariell Pettersson, David Bliman, Jimmy Jacobsson, Jesper Nilsson, J. Min, L. Iconaru, R. K. Guy, R. W. Kriwacki, Joakim Andréasson, Morten Grøtli
PLoS ONE - 2015 -
Design, Synthesis and Inhibitory Activity of Photoswitchable RET Kinase
Inhibitors.
Rubén Ferreira, Jesper Nilsson, Carlos Solano, Joakim Andréasson, Morten Grøtli
Scientific reports - 2015 -
Development of bright fluorescent quadracyclic adenine analogues: TDDFT-calculation supported rational
design
Anders Foller Larsen, Blaise Dumat, Moa Sandberg Wranne, Christopher P. Lawson, S. Preus, Mattias Bood, Henrik Gradén, Marcus Wilhelmsson, Morten Grøtli
Scientific Reports - 2015 -
Design, Synthesis and Evaluation of 2,5-Diketopiperazines as Inhibitors of the MDM2-p53
Interaction
Mariell Pettersson, Maria Quant, J. Min, L. Iconaru, R. W. Kriwacki, M. B. Waddell, R. K. Guy, Kristina Luthman, Morten Grøtli
PLoS ONE - 2015 -
The unique characteristics of HOG pathway MAPKs in the extremely halotolerant Hortaea
werneckii
A. Kejzar, M. Cibic, Morten Grøtli, A. Plemenitas, M. Lenassi
Fems Microbiology Letters - 2015
Fler publikationer
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